[Research progress of protein tyrosine phosphatase SHP-2]

Hong-ke Cai; Yong-chuan Deng

doi:10.3785/j.issn.1008-9292.2012.05.019

[Research progress of protein tyrosine phosphatase SHP-2]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Sep;41(5):581-5. doi: 10.3785/j.issn.1008-9292.2012.05.019.

[Article in Chinese]

Authors

Hong-ke Cai¹, Yong-chuan Deng

Affiliation

¹ Department of Surgical Oncology, Zhejiang University School of Medicine, Hangzhou, China.

PMID: 23086654
DOI: 10.3785/j.issn.1008-9292.2012.05.019

Abstract

The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.

Publication types

English Abstract
Review

MeSH terms

Humans
Protein Tyrosine Phosphatase, Non-Receptor Type 11* / chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 11* / metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 11* / physiology

Substances

Protein Tyrosine Phosphatase, Non-Receptor Type 11