Abstract
An 82-year-old man referred to our medical ward because of epistaxis and melena was found to have 12 Bethesda units of factor V inhibitor. He was managed for bleeding with supportive care, followed by corticosteroid therapy. The bleeding completely stopped 1 week after corticosteroid therapy. Medical history revealed dysphagia during the past 6 months and further evaluation brought to light a squamous cell carcinoma (SCC) in the esophagus. This is the first case of an acquired factor V inhibitor developing in a patient with esophageal SCC without any other risk factors such as surgery.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Aged, 80 and over
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Autoantibodies / biosynthesis
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Autoantibodies / immunology*
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Autoimmune Diseases / etiology
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Autoimmune Diseases / immunology*
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Carcinoma, Squamous Cell / complications
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / diagnostic imaging
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Carcinoma, Squamous Cell / immunology*
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Carcinoma, Squamous Cell / radiotherapy
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Deglutition Disorders / etiology
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Delayed Diagnosis
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Epistaxis / etiology
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Erythrocyte Transfusion
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Esophageal Neoplasms / complications
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Esophageal Neoplasms / diagnosis
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Esophageal Neoplasms / diagnostic imaging
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Esophageal Neoplasms / immunology*
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Esophageal Neoplasms / radiotherapy
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Factor V / antagonists & inhibitors
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Factor V / immunology*
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Factor V Deficiency / etiology
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Factor V Deficiency / immunology*
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Fatal Outcome
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Gastroscopy
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Hematuria / etiology
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Humans
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Immunosuppressive Agents / therapeutic use
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Lupus Coagulation Inhibitor / blood
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Male
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Melena / etiology
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Paraneoplastic Syndromes / etiology
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Paraneoplastic Syndromes / immunology*
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Prednisolone / therapeutic use
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Radiography
Substances
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Adrenal Cortex Hormones
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Autoantibodies
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Immunosuppressive Agents
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Lupus Coagulation Inhibitor
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Factor V
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Prednisolone