Abstract
A new formulation of a natural product shows remarkable activity against pancreatic ductal adenocarcinoma across a number of preclinical model systems. These findings set the stage for a clinical trial.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / therapeutic use*
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Carcinoma, Pancreatic Ductal / therapy*
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Clinical Trials as Topic
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Diterpenes / therapeutic use
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Drug Evaluation, Preclinical
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Epoxy Compounds / therapeutic use
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Humans
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Medical Oncology / trends
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Medicine, Chinese Traditional
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Organophosphates / therapeutic use
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Pancreatic Neoplasms / therapy*
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Phenanthrenes / therapeutic use
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Research Design
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Translational Research, Biomedical
Substances
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Antineoplastic Agents, Alkylating
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Diterpenes
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Epoxy Compounds
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Organophosphates
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Phenanthrenes
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triptolide
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14-O-phosphonooxymethyltriptolide disodium salt