Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes

Elina O Erra; Helena Hervius Askling; Sutee Yoksan; Lars Rombo; Jukka Riutta; Sirkka Vene; Lars Lindquist; Olli Vapalahti; Anu Kantele

doi:10.1093/cid/cis883

Cross-protective capacity of Japanese encephalitis (JE) vaccines against circulating heterologous JE virus genotypes

Clin Infect Dis. 2013 Jan;56(2):267-70. doi: 10.1093/cid/cis883. Epub 2012 Oct 16.

Authors

Elina O Erra¹, Helena Hervius Askling, Sutee Yoksan, Lars Rombo, Jukka Riutta, Sirkka Vene, Lars Lindquist, Olli Vapalahti, Anu Kantele

Affiliation

¹ Haartman Institute, University of Helsinki, Finland.

Abstract

Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antibodies, Neutralizing / immunology
Antibodies, Viral / immunology
Cross Reactions / immunology*
Encephalitis Virus, Japanese / genetics*
Encephalitis Virus, Japanese / immunology*
Encephalitis, Japanese / immunology
Encephalitis, Japanese / prevention & control*
Female
Genotype*
Humans
Japanese Encephalitis Vaccines / immunology*
Male
Middle Aged
Vaccines, Inactivated / immunology
Young Adult

Substances

Antibodies, Neutralizing
Antibodies, Viral
Japanese Encephalitis Vaccines
Vaccines, Inactivated