Pd-catalyzed Suzuki coupling reaction of chloroalkylidene-β-lactones with LB-Phos as the ligand

Pengbin Li; Bo Lü; Chunling Fu; Shengming Ma

doi:10.1039/c2ob26365c

Pd-catalyzed Suzuki coupling reaction of chloroalkylidene-β-lactones with LB-Phos as the ligand

Org Biomol Chem. 2013 Jan 7;11(1):98-109. doi: 10.1039/c2ob26365c.

Authors

Pengbin Li¹, Bo Lü, Chunling Fu, Shengming Ma

Affiliation

¹ Laboratory of Molecular Recognition and synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.

PMID: 23060006
DOI: 10.1039/c2ob26365c

Abstract

In this paper, LB-Phos·HBF(4) salt has been applied for the Pd-catalysed Suzuki coupling reactions of optically active (Z)-α-choroalkylidene-β-lactones. Aryl, vinyl, alkyl and heteroaromatic boronic acids may be coupled with optically active β-lactones affording corresponding optically active products highly selectively and efficiently.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boronic Acids / chemistry*
Catalysis
Lactones / chemical synthesis*
Lactones / chemistry
Ligands
Models, Molecular
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*

Substances

Boronic Acids
Lactones
Ligands
Organometallic Compounds
Palladium