Abstract
A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is described. Theoretical, NMR, and X-ray studies indicated that this azepane-derived amino acid is an effective stabilizer of 3(10) helical structures in short peptides.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Amino Acids / chemistry*
-
Azepines / chemistry*
-
Crystallography, X-Ray
-
Hydrogen Bonding
-
Molecular Conformation
-
Nuclear Magnetic Resonance, Biomolecular
-
Peptides / chemistry*
-
Protein Structure, Secondary
Substances
-
Amino Acids
-
Azepines
-
Peptides