Objective: To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine.
Methods: The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed.
Results: To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear.
Conclusion: The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.