Carbon distribution to toxic effect in toxin proteins

Bioinformation. 2012;8(15):720-1. doi: 10.6026/97320630008720. Epub 2012 Aug 3.

Abstract

The role of hydrophobic force in biological function through the formation of several local macro-molecular structures is evident. Carbon is the element that contributes to biological function in living systems. We show that carbon distribution is related to protein activity using an example. The carbon distribution profile is foreseen to help undestand unfolded and misfolded regions of protein structures. The carbon distribution profile in a toxin protein that is found associated with the toxic shock syndrome is described in this study. The carbon profile provides insight to the association of specific residues responsible for toxicity.

Keywords: carbon distribution; carbon profile; hydrophobic interation; mitogenicity; mutational study; toxic protein.