Abstract
Two new sesquiterpene pyridine alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside11-O-β-D-glucopyranosyl neotriptophenolide (4) and two known triterpenoids 23-noroxopristimerol(5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygiumhypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis.Compounds 1–3 were screened for their cytotoxic activities against five cancer celllines, but all of them were inactive.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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Plant Roots / chemistry
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Pyridines / chemistry
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Pyridines / isolation & purification*
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Pyridines / pharmacology
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Tripterygium / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Pyridines
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Saponins
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Sesquiterpenes
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Triterpenes
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hypoglaside A
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hypoglaunine E
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hypoglaunine F