Abstract
An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Interleukin-8 / chemistry
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Interleukin-8 / metabolism
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Peptides / chemistry
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Peptides / metabolism
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Periodic Acid / chemistry
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Proteins / chemistry*
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Proteins / metabolism
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Aldehydes
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Interleukin-8
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Peptides
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Proteins
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Periodic Acid
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metaperiodate