Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome

Gurpreet Singh; Xing Chang Wei; Walter Hader; Jennifer A Chan; Eric Bouffet; Lucie Lafay-Cousin

doi:10.1097/MPH.0b013e3182707e67

Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome

J Pediatr Hematol Oncol. 2013 Mar;35(2):e53-6. doi: 10.1097/MPH.0b013e3182707e67.

Authors

Gurpreet Singh¹, Xing Chang Wei, Walter Hader, Jennifer A Chan, Eric Bouffet, Lucie Lafay-Cousin

Affiliation

¹ Department of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, ON, Canada.

PMID: 23042016
DOI: 10.1097/MPH.0b013e3182707e67

Abstract

Diencephalic syndrome (DS) related to hypothalamic/chiasmatic region tumor has mainly been reported with low-grade glioma. We described 2 young children with DS related to pilomyxoid astrocytoma. Despite the recognized more agressive clinical behavior of this histologic subtype, we report successful resolution of DS and sustained tumor response with prolonged use of single-agent vinblastine.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / therapeutic use*
Astrocytoma / complications
Astrocytoma / drug therapy*
Female
Humans
Hypothalamic Diseases / drug therapy*
Hypothalamic Neoplasms / complications
Hypothalamic Neoplasms / drug therapy*
Infant
Male
Vinblastine / therapeutic use*

Substances

Antineoplastic Agents, Phytogenic
Vinblastine