Abstract
The B-cell receptor (BCR) complex and its associated protein tyrosine kinases play a critical role in the development, proliferation, and survival of normal or malignant B cells. Regulated activity of the BCR complex promotes the expansion of selected B cells and the deletion of unwanted or self-reactive ones. Compounds that inhibit various components of this pathway, including spleen tyrosine kinase, Bruton's tyrosine kinase, and phosphoinositol-3 kinase, have been developed. We summarize the rationale for use of agents that can inhibit BCR signaling to treat patients with either indolent or aggressive B-cell lymphomas, highlight early clinical results, and speculate on the future application of such agents in the treatment of patients with various B-cell lymphomas.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenine / analogs & derivatives
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Aminopyridines
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
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Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
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Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
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Lymphoma, Large B-Cell, Diffuse* / drug therapy
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Lymphoma, Large B-Cell, Diffuse* / metabolism
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Lymphoma, Large B-Cell, Diffuse* / pathology
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Lymphoma, Mantle-Cell* / drug therapy
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Lymphoma, Mantle-Cell* / metabolism
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Lymphoma, Mantle-Cell* / pathology
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Morpholines
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Neoplasm Staging
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Niacinamide / analogs & derivatives
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Niacinamide / therapeutic use
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Oxazines / therapeutic use
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Phenylurea Compounds / therapeutic use
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Phosphatidylinositol 3-Kinases / metabolism
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Phosphoinositide-3 Kinase Inhibitors
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Piperidines
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Protein-Tyrosine Kinases / metabolism
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Purines / therapeutic use
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Pyrazoles / therapeutic use
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Pyridines / therapeutic use
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Pyrimidines / therapeutic use
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Quinazolinones / therapeutic use
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Receptors, Antigen, B-Cell* / antagonists & inhibitors
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Receptors, Antigen, B-Cell* / chemistry
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Receptors, Antigen, B-Cell* / metabolism
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Signal Transduction
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Sorafenib
Substances
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Aminopyridines
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Morpholines
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Oxazines
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Phenylurea Compounds
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Phosphoinositide-3 Kinase Inhibitors
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Piperidines
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Purines
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Pyrazoles
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Pyridines
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Pyrimidines
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Quinazolinones
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Receptors, Antigen, B-Cell
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ibrutinib
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Niacinamide
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Sorafenib
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Protein-Tyrosine Kinases
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Adenine
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fostamatinib
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idelalisib