Abstract
We measured immune markers in subjects with multiple sclerosis (MS) treated with IFNβ-1b for 12 months. IL-17 levels were significantly higher at Month 6 (p=0.036) in relapsing subjects while BDNF levels were significantly higher at Month 3 (p=0.028) in relapse-free subjects. Change from baseline in IL-4 levels inversely correlated with disability score whereas change from baseline in IL-10/IFN-gamma ratio inversely correlated with occurrence of relapses. CXCR3+CD8+ T-cells tended to be higher but declined with treatment in relapse-free compared with relapsing subjects. Findings show the potential of cytokine and neurotrophic factors as biomarkers of clinical response to IFNβ-1b.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Clinical Trial, Phase IV
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Abortion, Habitual / prevention & control
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Adjuvants, Immunologic / therapeutic use*
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Adolescent
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Adult
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Cytokines / metabolism*
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Disability Evaluation
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Interferon beta-1b
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Interferon-beta / therapeutic use*
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Male
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Matrix Metalloproteinase 2 / metabolism
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Middle Aged
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Multiple Sclerosis / drug therapy*
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Multiple Sclerosis / immunology*
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Tissue Inhibitor of Metalloproteinase-2 / metabolism
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Vascular Cell Adhesion Molecule-1 / metabolism
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Young Adult
Substances
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Adjuvants, Immunologic
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Cytokines
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Vascular Cell Adhesion Molecule-1
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Tissue Inhibitor of Metalloproteinase-2
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Interferon beta-1b
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Interferon-beta
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Matrix Metalloproteinase 2