Two new nonacosanetriols from Ginkgo biloba sarcotesta

Chem Phys Lipids. 2012 Oct;165(7):731-6. doi: 10.1016/j.chemphyslip.2012.08.003. Epub 2012 Sep 6.

Abstract

Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Anticoagulants / chemistry
  • Anticoagulants / isolation & purification*
  • Anticoagulants / pharmacology
  • Blood Coagulation / drug effects
  • Chromatography, Gel
  • Chromatography, Thin Layer
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification*
  • Fatty Alcohols / pharmacology
  • Ginkgo biloba / chemistry*
  • In Vitro Techniques
  • Molecular Structure
  • Rabbits
  • Spectrometry, Mass, Electrospray Ionization
  • Stereoisomerism
  • Tandem Mass Spectrometry
  • Transition Temperature

Substances

  • (7S,8R,11S)-nonacosanetriol
  • Anticoagulants
  • Fatty Alcohols