Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study

Takeshi Nishimura; Kanji Yamaguchi; Hideki Fujii; Yorihisa Okada; Chihiro Yokomizo; Toshihisa Niimi; Yoshio Sumida; Kohichiroh Yasui; Hironori Mitsuyoshi; Masahito Minami; Atsushi Umemura; Toshihide Shima; Takeshi Okanoue; Yoshito Itoh

doi:10.1111/j.1872-034X.2012.01091.x

Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study

Hepatol Res. 2013 May;43(5):557-62. doi: 10.1111/j.1872-034X.2012.01091.x. Epub 2012 Sep 14.

Authors

Takeshi Nishimura¹, Kanji Yamaguchi, Hideki Fujii, Yorihisa Okada, Chihiro Yokomizo, Toshihisa Niimi, Yoshio Sumida, Kohichiroh Yasui, Hironori Mitsuyoshi, Masahito Minami, Atsushi Umemura, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh

Affiliation

¹ Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto.

PMID: 22978477
DOI: 10.1111/j.1872-034X.2012.01091.x

Abstract

Aim: This study examined serum alanine aminotransferase (ALT) levels at first visit and their relationship with long-term normal serum ALT levels in hepatitis C virus (HCV) carriers with persistently normal ALT (PNALT).

Methods: HCV carriers with PNALT were identified as those patients with positivity of serum HCV RNA, ALT levels of 30 IU/L or less over a 12-month period on at least three different occasions, platelet count of more than 15 × 10(4) μl/mL and body mass index of 30 kg/m(2) or less. Outcome was retrospectively studied in 49 HCV carriers with PNALT, who were followed up for more than 10 years.

Results: During the mean follow-up period of 14.7 ± 2.5 years, ALT levels of 30 IU/L or less were preserved in only eight patients (8/49; 16.3%). Among the 17 patients with initial ALT levels of 19 IU/L or less, nine patients remained with ALT levels of 30 IU/L or less after 10 years (9/17; 52.9%). The probability of ALT levels in PNALT being maintained at 30 IU/L or less was significantly higher (P = 0.001) in these patients than in those with initial ALT levels of 20 IU/L or more (n = 32). Abnormal ALT levels were more common in female PNALT patients aged 45-55 years, which is usually the time of menopause onset.

Conclusion: Because antiviral therapy in the treatment of chronic hepatitis C is rapidly advancing, waiting for more effective and safer treatments may be an option. The results of this study provide an important insight into this issue.