In this study, we analyzed the relationship between running economy (RE) and biomechanical parameters in a group running at the same relative intensity and same absolute velocity. Sixteen homogeneous male long-distance runners performed a test to determine RE at 4.4 m.s(-1), corresponding to 11.1% below velocity at the ventilatory threshold. We found significant correlations between RE and biomechanical variables (vertical oscillation of the center of mass, stride frequency, stride length, balance time, relative stride length, range of elbow motion, internal knee, ankle angles at foot strike, and electromyographic activity of the semitendinosus and rectus femoris muscles). In conclusion, changes in running technique can influence RE and lead to improved running performance.