Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response

A A Ligacheva; A N Ivanova; Yu P Belsky; N V Belska; E S Trofimova; M G Danilets; A M Dygai

doi:10.1007/s10517-012-1743-3

Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response

Bull Exp Biol Med. 2012 Aug;153(4):472-4. doi: 10.1007/s10517-012-1743-3.

[Article in English, Russian]

Authors

A A Ligacheva¹, A N Ivanova, Yu P Belsky, N V Belska, E S Trofimova, M G Danilets, A M Dygai

Affiliation

¹ Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. vittelli@mail.ru

PMID: 22977847
DOI: 10.1007/s10517-012-1743-3

Abstract

We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. Both substances reduced edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response induced with ovalbumin (Th2-dependent response). The anti-inflammatory effects of aurothiomalate were similar to those of voltaren during Th1-type immune response.

Publication types

Comparative Study

MeSH terms

Analysis of Variance
Animals
Cytokines / immunology
Diclofenac / pharmacology
Diclofenac / therapeutic use
Erythrocytes
Female
Gold Sodium Thiomalate / pharmacology*
Gold Sodium Thiomalate / therapeutic use
Hypersensitivity, Delayed / chemically induced
Hypersensitivity, Delayed / drug therapy*
Hypersensitivity, Immediate / chemically induced
Hypersensitivity, Immediate / drug therapy*
Immunity, Cellular / immunology*
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
NF-kappa B / antagonists & inhibitors*
Ovalbumin / toxicity
Th1 Cells / immunology*
Th2 Cells / immunology*

Substances

Cytokines
NF-kappa B
Gold Sodium Thiomalate
Diclofenac
Ovalbumin