High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species

Sigalit Meker; Katrin Margulis-Goshen; Ester Weiss; Shlomo Magdassi; Edit Y Tshuva

doi:10.1002/anie.201205973

High antitumor activity of highly resistant salan-titanium(IV) complexes in nanoparticles: an identified active species

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10515-7. doi: 10.1002/anie.201205973. Epub 2012 Sep 7.

Authors

Sigalit Meker¹, Katrin Margulis-Goshen, Ester Weiss, Shlomo Magdassi, Edit Y Tshuva

Affiliation

¹ Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.

PMID: 22961758
DOI: 10.1002/anie.201205973

Abstract

A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan-Ti(IV) complex shows high antitumor activity, which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti(IV) can provide high cytotoxicity with controlled biological function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Drug Screening Assays, Antitumor
Humans
Models, Molecular
Nanoparticles / chemistry
Nanoparticles / therapeutic use*
Structure-Activity Relationship
Titanium / chemistry
Titanium / pharmacology*

Substances

Antineoplastic Agents
Coordination Complexes
Titanium