An efficient total synthesis of a potent anti-inflammatory agent, benzocamphorin F, and its anti-inflammatory activity

Yu-Ren Liao; Ping-Chung Kuo; Jun-Weil Liang; Yuh-Chiang Shen; Tian-Shung Wu

doi:10.3390/ijms130810432

An efficient total synthesis of a potent anti-inflammatory agent, benzocamphorin F, and its anti-inflammatory activity

Int J Mol Sci. 2012;13(8):10432-10440. doi: 10.3390/ijms130810432. Epub 2012 Aug 21.

Authors

Yu-Ren Liao¹, Ping-Chung Kuo², Jun-Weil Liang¹, Yuh-Chiang Shen³, Tian-Shung Wu^{1

4

5}

Affiliations

¹ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
² Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan.
³ National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
⁴ Department of Pharmacy, China Medical University, Taichung 401, Taiwan.
⁵ Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung 401, Taiwan.

Abstract

A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.

Keywords: Antrodia camphorata; anti-inflammatory; benzocamphorin F.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemical synthesis*
Anti-Inflammatory Agents / pharmacology*
Antrodia / chemistry*
Benzene Derivatives / chemical synthesis*
Benzene Derivatives / pharmacology*
Cells, Cultured
Free Radical Scavengers / chemical synthesis
Free Radical Scavengers / pharmacology
Mice
Microglia / cytology
Microglia / drug effects*
Models, Molecular
Molecular Structure
Nitric Oxide / metabolism*
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Benzene Derivatives
Free Radical Scavengers
benzocamphorin F
Nitric Oxide