In order to explore the residue characteristics and distributions of 15 perfluorinated compounds (PFCs) in 18 surface seawater samples along Shenzhen coastline, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) combined with solid phase extraction enrichment was applied in this research. The results indicated that residue level of PFCs in coastal surface seawater samples was significantly affected by human activities. Sigma PFCs residue levels in surface seawater from Shenzhen west coast, which locates below the estuary of Pearl River and Donghao River, are much higher than those from the east coast, which has low development and sparse population (P<0.05). Under natural conditions, sigma PFCs residue levels in coastal surface seawater samples from Shenzhen Bays are higher than those out of bays. The major residue species in surface seawater samples along Shenzhen coast were medium- and short-chain PFCs, including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanoic acid and perfluoropentanoic acid. Their similar environmental behavior (P<0.05, P<0.01) is likely associated with the production process of PFCs-related products. Furthermore, cluster analysis results show that PFOS (R2 = 0.4092) level can be used as a representative parameter for evaluating PFCs contamination status in surface seawater along Shenzhen coast.