Design of a "turn-off/turn-on" biosensor: understanding carbohydrate-lectin interactions for use in noncovalent drug delivery

Bala Kishan Gorityala; Zhiqiang Lu; Min Li Leow; Jimei Ma; Xue-Wei Liu

doi:10.1021/ja306288p

Design of a "turn-off/turn-on" biosensor: understanding carbohydrate-lectin interactions for use in noncovalent drug delivery

J Am Chem Soc. 2012 Sep 19;134(37):15229-32. doi: 10.1021/ja306288p. Epub 2012 Sep 10.

Authors

Bala Kishan Gorityala¹, Zhiqiang Lu, Min Li Leow, Jimei Ma, Xue-Wei Liu

Affiliation

¹ Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.

PMID: 22935034
DOI: 10.1021/ja306288p

Abstract

A low-cost and highly sensitive biosensor system is designed to investigate carbohydrate-lectin interactions. This combination of glyco-gold nanoparticles and boronic acid biosensor system opens a way to study noncovalent drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Carbohydrates / chemistry*
Drug Delivery Systems*
Lectins / chemistry*
Nanoparticles
Spectrometry, Fluorescence

Substances

Carbohydrates
Lectins