The patients with "Diabetes Mellitus", "Hypertension" and "Hyperlipidemia" are accompanied with an osteoporosis. It is well known that increased fracture risk is observed in diabetes mellitus. Some reports indicate increased fracture risk in hypertension, arterial calcification and ischemic heart disease. Vascular calcification is an active process similar to physiological mineralization of skeletal tissues. A number of factors were reported to regulate differentiation of multiple cell types among bone and blood vessels. Thus, bone metabolism-related factors activities participate in vascular calcification. However, the effective treatment for suppressing the progression of vascular calcification has not been established. Here we will review recent advances in the researches of mutual connection between bone and blood vessel and present our findings that the SERM or bisphosphonate are useful in prevention of vascular calcification in diabetes.