Quantum dot applications endowing novelty to analytical proteomics

Hui-Fen Wu; Judy Gopal; Hani Nasser Abdelhamid; Nazim Hasan

doi:10.1002/pmic.201200295

Quantum dot applications endowing novelty to analytical proteomics

Proteomics. 2012 Oct;12(19-20):2949-61. doi: 10.1002/pmic.201200295.

Authors

Hui-Fen Wu¹, Judy Gopal, Hani Nasser Abdelhamid, Nazim Hasan

Affiliation

¹ Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan. hwu@faculty.nsysu.edu.tw

PMID: 22930415
DOI: 10.1002/pmic.201200295

Abstract

This review surveys all the state-of-art applications of quantum dots (QDs) in conventional and modern analytical methods in proteomic studies. A brief introduction of QDs and their properties is initially presented followed by outlining the application of QDs in fluorescence, MS, imaging, and cancer-based proteomics. The in-depth application of QDs in MALDI-MS and surface assisted laser desorption/ionization-MS has been elaborately discussed, summarizing the speculated mechanism behind the protein-QDs interactions during QD matrix applications leading to enhanced detection sensitivity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Molecular Imaging / methods
Nanotechnology / methods
Proteomics / methods*
Quantum Dots*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods