Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers

J Biomed Mater Res A. 2013 Mar;101(3):613-21. doi: 10.1002/jbm.a.34359. Epub 2012 Aug 28.

Abstract

Polypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T(1) measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Contrast Media / chemistry*
  • Contrast Media / pharmacology
  • Dendrimers / chemistry*
  • Dendrimers / pharmacology
  • Drug Evaluation, Preclinical
  • Fibroblasts / cytology
  • Fibroblasts / metabolism
  • Gadolinium DTPA / chemistry*
  • Gadolinium DTPA / pharmacology
  • Humans
  • Polypropylenes / chemistry*
  • Polypropylenes / pharmacology

Substances

  • Contrast Media
  • Dendrimers
  • Polypropylenes
  • poly(propyleneimine)
  • Gadolinium DTPA