Total synthesis of epiberberine

J Asian Nat Prod Res. 2012;14(9):873-6. doi: 10.1080/10286020.2012.701621. Epub 2012 Aug 28.

Abstract

Epiberberine, a natural bioactive protoberberine alkaloid, was totally synthesized in short, convenient and low-cost, four-step reactions including cyclization, condensation, reduction, and ring-closing, with an overall yield of 26.1%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Berberine / analogs & derivatives*
  • Berberine / chemical synthesis
  • Berberine / chemistry
  • Berberine Alkaloids / chemical synthesis*
  • Berberine Alkaloids / chemistry
  • Catalysis
  • Cyclization
  • Molecular Structure

Substances

  • Berberine Alkaloids
  • Berberine
  • protoberberine
  • epiberberine