MCM structure and mechanics: what we have learned from archaeal MCM

Ian M Slaymaker; Xiaojiang S Chen

doi:10.1007/978-94-007-4572-8_6

MCM structure and mechanics: what we have learned from archaeal MCM

Subcell Biochem. 2012:62:89-111. doi: 10.1007/978-94-007-4572-8_6.

Authors

Ian M Slaymaker¹, Xiaojiang S Chen

Affiliation

¹ Molecular and Computational Biology, University of Southern California, Los Angeles, CA, 90089, USA.

PMID: 22918582
DOI: 10.1007/978-94-007-4572-8_6

Abstract

Minichromosome maintenance (MCM) complexes have been identified as the primary replicative helicases responsible for unwinding DNA for genome replication. The focus of this chapter is to discuss the current structural and functional understanding of MCMs and their role at origins of replication, which are based mostly on the studies of MCM proteins and MCM complexes from archaeal genomes.

Publication types

Review

MeSH terms

Archaea / physiology*
Archaeal Proteins / genetics
Archaeal Proteins / metabolism*
DNA Replication / physiology*
DNA, Archaeal / biosynthesis*
DNA, Archaeal / genetics
Genome, Archaeal / physiology*
Minichromosome Maintenance Proteins / genetics
Minichromosome Maintenance Proteins / metabolism*

Substances

Archaeal Proteins
DNA, Archaeal
Minichromosome Maintenance Proteins