Flash generation of a highly reactive Pd catalyst for Suzuki-Miyaura coupling by using a flow microreactor

Aiichiro Nagaki; Naofumi Takabayashi; Yuya Moriwaki; Jun-ichi Yoshida

doi:10.1002/chem.201201579

Flash generation of a highly reactive Pd catalyst for Suzuki-Miyaura coupling by using a flow microreactor

Chemistry. 2012 Sep 17;18(38):11871-5. doi: 10.1002/chem.201201579. Epub 2012 Aug 17.

Authors

Aiichiro Nagaki¹, Naofumi Takabayashi, Yuya Moriwaki, Jun-ichi Yoshida

Affiliation

¹ Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510, Japan.

PMID: 22903340
DOI: 10.1002/chem.201201579

Abstract

Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)(2)] and that of tBu(3) P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki-Miyaura coupling was conducted (see scheme).