A highly sensitive fluorescent viscosity sensor

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5780-3. doi: 10.1016/j.bmcl.2012.07.101. Epub 2012 Aug 4.

Abstract

Variation at the 3' position of fluorescein via Suzuki-Miyaura cross-coupling with aryl and heteroaryl moieties gave a family of anthofluoresceins whose spectroscopic properties were studied. The 1-methylindole derivative gave the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluoresceins / chemical synthesis
  • Fluoresceins / chemistry*
  • Fluorescence Polarization
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Spectrometry, Fluorescence
  • Viscosity

Substances

  • Fluoresceins
  • Fluorescent Dyes