Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis

Mai Lin; David Ranganathan; Tetsuya Mori; Aviv Hagooly; Raffaella Rossin; Michael J Welch; Suzanne E Lapi

doi:10.1016/j.apradiso.2012.05.009

Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis

Appl Radiat Isot. 2012 Oct;70(10):2539-44. doi: 10.1016/j.apradiso.2012.05.009. Epub 2012 Jun 19.

Authors

Mai Lin¹, David Ranganathan, Tetsuya Mori, Aviv Hagooly, Raffaella Rossin, Michael J Welch, Suzanne E Lapi

Affiliation

¹ Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

PMID: 22897970
DOI: 10.1016/j.apradiso.2012.05.009

Abstract

Interest in using (68)Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO(2)-based (68)Ge/(68)Ga generators and develop an optimized automation strategy to synthesize [(68)Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of (68)Ge/(68)Ga generators and automation strategies to comply with regulatory issues for clinical use.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Automation
Gallium Radioisotopes / chemistry*
Germanium / chemistry*
Octreotide / analogs & derivatives*
Octreotide / chemical synthesis
Titanium / chemistry*

Substances

Gallium Radioisotopes
Germanium
titanium dioxide
Titanium
Octreotide
Edotreotide