Incidence and outcome of early Candida peritonitis after liver and pancreas transplantation

Mycoses. 2013 Mar;56(2):162-7. doi: 10.1111/j.1439-0507.2012.02227.x. Epub 2012 Aug 17.

Abstract

Candida peritonitis is a potentially life-threatening infection after abdominal transplantation, although there is scant information regarding its incidence and outcome. We analysed the incidence rate and outcome of Candida peritonitis in 717 liver or pancreas transplant recipients. Five cases of Candida peritonitis were diagnosed, representing the second most frequent cause of invasive fungal infection in the cohort. The incidence rate of Candida peritonitis during the first 30 days after transplantation was 6.5 cases/10 000 transplant days in pancreas recipients and 1.2 cases/10 000 transplant days in liver recipients (P = 0.035). Four of the five patients received an echinocandin in combination with other antifungal. All patients were alive and with good graft function at 1-year follow-up. In our series, Candida peritonitis in liver and pancreas transplant recipients was not uncommon and had a good prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Candida
  • Candidiasis / drug therapy
  • Candidiasis / epidemiology*
  • Candidiasis / etiology
  • Candidiasis / microbiology
  • Cohort Studies
  • Female
  • Humans
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Pancreas Transplantation / adverse effects*
  • Peritonitis / drug therapy
  • Peritonitis / epidemiology
  • Peritonitis / etiology
  • Peritonitis / microbiology
  • Postoperative Complications / drug therapy
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Postoperative Complications / microbiology
  • Prospective Studies

Substances

  • Antifungal Agents