Abstract
The antitumor activities of DOX-loaded alginic acid/poly[2-(diethylamino)ethyl methacrylate] (ALG-PDEA) nanoparticles are evaluated both in vitro and in vivo. TEM imaging shows that the ALG-PDEA NPs have a spherical morphology with a size of about 120 nm. CLSM observations reveal that the negatively charged ALG-PDEA NPs can be taken up well by cells. In vivo NIR fluorescence imaging shows that the ALG-PDEA NPs can passively target the tumor area because of the EPR effect in the H22 tumor-bearing mouse. In vivo antitumor efficacy examinations indicate that DOX-loaded ALG-PDEA NPs have significantly superior efficacy in impeding tumor growth compared to free DOX and low toxicity to living mice.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alginates*
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Animals
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / pharmacokinetics
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Antibiotics, Antineoplastic / pharmacology*
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Biological Transport
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Cell Line, Tumor
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Cell Survival / drug effects
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Doxorubicin / administration & dosage
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Doxorubicin / pharmacokinetics
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Doxorubicin / pharmacology*
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Drug Carriers
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Drug Compounding
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Fluorescent Dyes
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / pathology
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Male
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Mice
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Mice, Inbred ICR
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Microscopy, Electron, Transmission
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Microscopy, Fluorescence
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Nanoparticles
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Neoplasm Transplantation
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Optical Imaging
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Particle Size
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Polymethacrylic Acids*
Substances
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Alginates
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Antibiotics, Antineoplastic
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Drug Carriers
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Fluorescent Dyes
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Polymethacrylic Acids
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alginic acid-poly(2-(diethylamino)ethyl methacrylate)
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Doxorubicin