The RSV fusion receptor: not what everyone expected it to be

Peter Mastrangelo; Richard G Hegele

doi:10.1016/j.micinf.2012.07.015

The RSV fusion receptor: not what everyone expected it to be

Microbes Infect. 2012 Nov;14(13):1205-10. doi: 10.1016/j.micinf.2012.07.015. Epub 2012 Jul 31.

Authors

Peter Mastrangelo¹, Richard G Hegele

Affiliation

¹ Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

PMID: 22884716
DOI: 10.1016/j.micinf.2012.07.015

Abstract

This article reviews current knowledge about respiratory syncytial virus (RSV) binding and entry into cells. The recent discovery of Nucleolin as a fusion receptor for RSV opens new avenues for developing interventions, while raising questions concerning RSV pathobiology and tropism. We also discuss characteristics of a good RSV drug target.

Publication types

Review

MeSH terms

Animals
Cell Line
Humans
Nucleolin
Phosphoproteins / metabolism*
RNA-Binding Proteins / metabolism*
Receptors, Virus / metabolism*
Respiratory Syncytial Virus Infections / virology*
Respiratory Syncytial Virus, Human / metabolism
Respiratory Syncytial Virus, Human / physiology*
Viral Fusion Proteins / metabolism
Viral Tropism
Virus Attachment
Virus Internalization

Substances

Phosphoproteins
RNA-Binding Proteins
Receptors, Virus
Viral Fusion Proteins