Midazolam-induced acute dystonia reversed by diazepam

J Anaesthesiol Clin Pharmacol. 2012 Jul;28(3):368-70. doi: 10.4103/0970-9185.98346.

Abstract

Midazolam can induce acute dystonia in childhood. We report the development of acute dystonia in a 6-year-old girl after receiving midazolam as a sedative. Dystonic contractions persisted despite flumazenil and biperiden lactate injections and the patient was treated with diazepam. Acute dystonia was rapidly abolished after the administration of diazepam intravenously. Diazepam may be an effective treatment option in patients who are unresponsive to flumazenil.

Keywords: Acute dystonia; diazepam; midazolam.

Publication types

  • Case Reports