This paper assesses the influence of (differential) settlement on sewer system functioning. Based on historical data of the vertical position of sewer invert levels, tilt measurements and in-sewer inspection videos, settlement and settlement related influences are analyzed for a case study area in Amsterdam. The average settlement rate of this system was 4 mm/year. Given this settlement rate, it is shown that settlement significantly influences sewer system functioning within the lifetime of a sewer (system).