Three new cembranoids from the Taiwanese soft coral Sarcophyton ehrenbergi

Shang-Kwei Wang; Mu-Keng Hsieh; Chang-Yih Duh

doi:10.3390/md10071433

Three new cembranoids from the Taiwanese soft coral Sarcophyton ehrenbergi

Mar Drugs. 2012 Jul;10(7):1433-1444. doi: 10.3390/md10071433. Epub 2012 Jun 27.

Authors

Shang-Kwei Wang^{1

2}, Mu-Keng Hsieh³, Chang-Yih Duh^{1

3}

Affiliations

¹ Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
³ Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Abstract

In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B (2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1-3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).

Keywords: Sarcophyton ehrenbergi; anti-HCMV; cembranoids; cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cytomegalovirus / drug effects
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Humans
Magnetic Resonance Spectroscopy
Mice
Taiwan

Substances

Diterpenes