Abstract
Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-α, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aspartate Aminotransferases / blood
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Cardiotonic Agents / pharmacology*
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Cardiotonic Agents / therapeutic use
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Creatine Kinase / blood
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Drug Evaluation, Preclinical
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Glycoproteins / pharmacology*
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Glycoproteins / therapeutic use
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Heart Ventricles / drug effects
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Heart Ventricles / metabolism
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Heart Ventricles / pathology
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Interleukin-8 / blood
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L-Lactate Dehydrogenase / blood
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Malondialdehyde / blood
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Malondialdehyde / metabolism
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Myocardial Reperfusion Injury / blood
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Myocardial Reperfusion Injury / prevention & control*
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Oxidative Stress
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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Superoxide Dismutase / blood
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Troponin I / blood
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Tumor Necrosis Factor-alpha / blood
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Ventricular Pressure / drug effects
Substances
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Cardiotonic Agents
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Glycoproteins
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Interleukin-8
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Troponin I
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Tumor Necrosis Factor-alpha
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Malondialdehyde
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L-Lactate Dehydrogenase
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Superoxide Dismutase
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Aspartate Aminotransferases
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Creatine Kinase
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urinastatin