Screening of counterfeit corticosteroid in creams and ointments by NMR spectroscopy

J Pharm Biomed Anal. 2012 Nov:70:245-50. doi: 10.1016/j.jpba.2012.07.005. Epub 2012 Jul 14.

Abstract

It has been shown that NMR spectroscopy is an effective analytical method to rapidly screen creams and ointments for counterfeit corticosteroids. Extraction and NMR procedures have been developed. Ten over the counter creams and ointments sold in health care shops were screened and two creams were found to contain counterfeited corticosteroids.

MeSH terms

  • Adrenal Cortex Hormones / analysis*
  • Calibration
  • Chemical Fractionation
  • Chromatography, Liquid
  • Counterfeit Drugs / analysis*
  • Fraud*
  • Magnetic Resonance Spectroscopy* / standards
  • Ointments
  • Quality Control
  • Reference Standards
  • Skin Cream
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Adrenal Cortex Hormones
  • Counterfeit Drugs
  • Ointments