Abstract
Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplified within families.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Antitubercular Agents / pharmacology*
-
Antitubercular Agents / therapeutic use
-
Drug Resistance, Multiple, Bacterial* / genetics
-
Extensively Drug-Resistant Tuberculosis / diagnosis
-
Extensively Drug-Resistant Tuberculosis / epidemiology
-
Extensively Drug-Resistant Tuberculosis / microbiology
-
Extensively Drug-Resistant Tuberculosis / transmission*
-
Family*
-
Female
-
Humans
-
Infant
-
Male
-
Microbial Sensitivity Tests
-
Mycobacterium tuberculosis / drug effects*
-
Mycobacterium tuberculosis / genetics
-
Mycobacterium tuberculosis / isolation & purification
-
South Africa / epidemiology
-
Tuberculosis, Multidrug-Resistant / drug therapy
-
Tuberculosis, Multidrug-Resistant / epidemiology
-
Tuberculosis, Multidrug-Resistant / microbiology
-
Tuberculosis, Multidrug-Resistant / transmission*