Abstract
Two new sesterterpenoids named flabelliferins A (1) and B (2) were isolated from the lipophilic extract of the sponge Cateriospongia flabellifera, collected in the South Pacific near Vanuatu. The structure and absolute configuration of these two compounds were assigned by a combination of one- and two-dimensional NMR spectroscopy and by Mosher's ester analysis. Flabelliferin A (1) has a rare 25-homocheilanthane carbon skeleton, while flabelliferin B (2) is a 24-nor-25-homoscalarane sesterterpenoid.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Porifera / chemistry*
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Sesterterpenes / chemistry
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Sesterterpenes / isolation & purification*
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Sesterterpenes / pharmacology
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Vanuatu
Substances
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Antineoplastic Agents
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Sesterterpenes
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flabelliferin A
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flabelliferin B