[Association of rs10912745 and rs4916375 polymorphisms located in the cluster of flavin-containing monooxygenase genes, with ischaemic cardioembolic stroke]

T V Tupitsyna; E A Bondarenko; P A Slominskiĭ; I M Shetova; N A Shamalov; D Iu Timofeev; V I Skvortsova; S A Limborskaia

[Association of rs10912745 and rs4916375 polymorphisms located in the cluster of flavin-containing monooxygenase genes, with ischaemic cardioembolic stroke]

Genetika. 2012 May;48(5):672-5.

[Article in Russian]

Authors

T V Tupitsyna, E A Bondarenko, P A Slominskiĭ, I M Shetova, N A Shamalov, D Iu Timofeev, V I Skvortsova, S A Limborskaia

PMID: 22830265

Abstract

Twenty-one SNPs located in the cluster of genes FMO1-FMO2-FMO3-FMO4 and adjacent areas were analyzed in the patients with ischaemic cardioembolic stroke and in the control group. Significant differences between these samples were found in the distribution of genotype and allele differences in two polymorphic loci, rs10912745 and rs4916375. It was shown that these polymorphic loci are associated with the risk of ischaemic cardioembolic stroke development.

Publication types

English Abstract

MeSH terms

Cardiovascular Diseases / genetics*
Female
Genetic Association Studies
Humans
Ischemia / genetics*
Multigene Family / genetics
Oxygenases / genetics*
Polymorphism, Single Nucleotide
Risk Factors
Stroke / genetics*

Substances

Oxygenases
dimethylaniline monooxygenase (N-oxide forming)