Construction of an open-access QT database for detecting the proarrhythmia potential of marketed drugs: ECG-ViEW

Clin Pharmacol Ther. 2012 Sep;92(3):393-6. doi: 10.1038/clpt.2012.93. Epub 2012 Jul 25.

Abstract

Information about the QT interval from surface electrocardiograms (ECGs) is essential for surveillance of the proarrhythmia potential of marketed drugs. However, ECG records obtained in daily practice cannot be easily used for this purpose without labor-intensive manual effort. This study was aimed at constructing an open-access QT database, the Electrocardiogram Vigilance with Electronic Data Warehouse (ECG-ViEW). This longitudinal observational database contains 710,369 measurements of QT and associated clinical data from 371,401 patients. The de-identified database is freely available at http://www.ecgview.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Access to Information*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arrhythmias, Cardiac / chemically induced*
  • Child
  • Child, Preschool
  • Databases, Factual*
  • Drug-Related Side Effects and Adverse Reactions*
  • Electrocardiography / drug effects*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Young Adult