New 19-oxygenated steroids from the soft coral Nephthea chabrolii

Shang-Kwei Wang; Shyh-Yueh Puu; Chang-Yih Duh

doi:10.3390/md10061288

New 19-oxygenated steroids from the soft coral Nephthea chabrolii

Mar Drugs. 2012 Jun;10(6):1288-1296. doi: 10.3390/md10061288. Epub 2012 Jun 6.

Authors

Shang-Kwei Wang^{1

2}, Shyh-Yueh Puu³, Chang-Yih Duh^{1

3}

Affiliations

¹ Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
³ Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Abstract

In order to search for novel bioactive substances from marine organisms, we investigated the acetone extract of the soft coral Nephthea chabrolii collected at San-Hsian-Tai, Taitong County, Taiwan. From this extract three new 19-oxygenated steroids, nebrosteroids N-P (1-3) were isolated. The structures of these compounds were elucidated by extensive spectroscopic analyses.

Keywords: 19-oxygenated steroids; Nephthea chabrolii; anti-HCMV; cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Aquatic Organisms / chemistry*
Biological Products / chemistry
Biological Products / isolation & purification*
Biological Products / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Steroids / chemistry
Steroids / isolation & purification*
Steroids / pharmacology*
Taiwan

Substances

Antineoplastic Agents
Biological Products
Steroids