HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

Immunobiology. 2013 Apr;218(4):543-7. doi: 10.1016/j.imbio.2012.06.012. Epub 2012 Jun 28.

Abstract

Homozygosity for a 32 bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / genetics*
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / therapy
  • Alleles*
  • Base Sequence*
  • Female
  • HIV-1*
  • HLA-A24 Antigen / genetics*
  • HLA-A24 Antigen / immunology
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Humans
  • Immunity, Cellular / genetics
  • Immunity, Cellular / immunology
  • Male
  • Receptors, CCR5 / genetics*
  • Receptors, CCR5 / immunology
  • Sequence Deletion*
  • T-Lymphocytes / immunology

Substances

  • HLA-A*24:02 antigen
  • HLA-A24 Antigen
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • Receptors, CCR5