Transient severe non-proliferative retinopathy in an adolescent with type 1 diabetes and chronic myeloid leukemia

Pediatr Diabetes. 2013 May;14(3):227-9. doi: 10.1111/j.1399-5448.2012.00901.x. Epub 2012 Jul 23.

Abstract

The onset of diabetic retinopathy correlates with the long-term quality of glycemic control. A 17-yr-old adolescent with type 1 diabetes presented unexpectedly with acute non-proliferative retinopathy despite good glycemic control. Two months later chronic myeloid leukemia (CML) was diagnosed. Chemotherapy was initiated and within a few weeks the patient was in full remission concerning leukemia. Retinopathy completely resolved within 8 months. The patient was in good metabolic control throughout the course. To our knowledge, this is the first report of CML-triggered retinopathy in a well-controlled diabetic adolescent. In case of unexpected retinopathy in patients with type 1 diabetes, other potential causes of retinopathy should be considered.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetic Retinopathy / complications
  • Diabetic Retinopathy / diagnosis
  • Diagnostic Errors
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology*
  • Male
  • Paraneoplastic Syndromes, Ocular / diagnosis
  • Paraneoplastic Syndromes, Ocular / etiology*
  • Paraneoplastic Syndromes, Ocular / prevention & control
  • Remission Induction
  • Severity of Illness Index