New monoterpenes, diterpenes, and lignans from Abies recurvata

Planta Med. 2012 Sep;78(14):1574-8. doi: 10.1055/s-0032-1315111. Epub 2012 Jul 19.

Abstract

From the aerial part of Abies recurvata, 62 miscellaneous chemical constituents were isolated including 6 new and 56 known ones. The new compounds comprised three monoterpenes, two diterpenes, and one lignan. Their chemical structures were characterized on the basis of various spectroscopic techniques. Dihydrodehydrodiconiferyl alcohol (35) showed the strongest inhibitory effects against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC₅₀ value of 66.4 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abies / chemistry*
  • Animals
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Inhibitory Concentration 50
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology
  • Lignin / analogs & derivatives
  • Lignin / pharmacology
  • Lipopolysaccharides / adverse effects
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology
  • Nitric Oxide / analysis
  • Nitric Oxide / metabolism
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • Diterpenes
  • Lignans
  • Lipopolysaccharides
  • Monoterpenes
  • Plant Extracts
  • Triterpenes
  • pinonesinol
  • Nitric Oxide
  • Lignin