Abstract
From the aerial part of Abies recurvata, 62 miscellaneous chemical constituents were isolated including 6 new and 56 known ones. The new compounds comprised three monoterpenes, two diterpenes, and one lignan. Their chemical structures were characterized on the basis of various spectroscopic techniques. Dihydrodehydrodiconiferyl alcohol (35) showed the strongest inhibitory effects against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC₅₀ value of 66.4 µM.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abies / chemistry*
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Animals
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Cell Line, Tumor
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Inhibitory Concentration 50
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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Lignin / analogs & derivatives
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Lignin / pharmacology
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Lipopolysaccharides / adverse effects
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Macrophages / drug effects
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Mice
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Molecular Structure
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Monoterpenes / chemistry*
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Monoterpenes / isolation & purification
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Monoterpenes / pharmacology
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Nitric Oxide / analysis
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Nitric Oxide / metabolism
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Plant Components, Aerial / chemistry
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Diterpenes
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Lignans
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Lipopolysaccharides
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Monoterpenes
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Plant Extracts
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Triterpenes
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pinonesinol
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Nitric Oxide
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Lignin