Abstract
A child with Job's syndrome was treated for pneumonia due to Mycoplasma pneumoniae. A mixed population of wild-type bacteria and an A2059G mutant was detected during josamycin treatment failure. The same multilocus variable-number tandem-repeat analysis (MLVA) type (MLVA type I) was isolated before and after treatment failure. The child recovered after ciprofloxacin treatment.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Child
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Ciprofloxacin / administration & dosage
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Drug Resistance, Bacterial*
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Humans
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Lung Diseases, Interstitial / drug therapy*
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Lung Diseases, Interstitial / microbiology
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Macrolides / pharmacology
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Macrolides / therapeutic use*
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Male
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Minisatellite Repeats*
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Mutation
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Mycoplasma pneumoniae / classification
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Mycoplasma pneumoniae / drug effects
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Mycoplasma pneumoniae / genetics
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Mycoplasma pneumoniae / isolation & purification*
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Pneumonia, Mycoplasma / drug therapy*
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Pneumonia, Mycoplasma / microbiology
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Salvage Therapy / methods
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Treatment Failure
Substances
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Anti-Bacterial Agents
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Macrolides
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Ciprofloxacin