Multilocus variable-number tandem-repeat analysis-confirmed emergence of a macrolide resistance-associated mutation in Mycoplasma pneumoniae during macrolide therapy for interstitial pneumonia in an immunocompromised child

J Clin Microbiol. 2012 Oct;50(10):3402-5. doi: 10.1128/JCM.01248-12. Epub 2012 Jul 18.

Abstract

A child with Job's syndrome was treated for pneumonia due to Mycoplasma pneumoniae. A mixed population of wild-type bacteria and an A2059G mutant was detected during josamycin treatment failure. The same multilocus variable-number tandem-repeat analysis (MLVA) type (MLVA type I) was isolated before and after treatment failure. The child recovered after ciprofloxacin treatment.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Ciprofloxacin / administration & dosage
  • Drug Resistance, Bacterial*
  • Humans
  • Lung Diseases, Interstitial / drug therapy*
  • Lung Diseases, Interstitial / microbiology
  • Macrolides / pharmacology
  • Macrolides / therapeutic use*
  • Male
  • Minisatellite Repeats*
  • Mutation
  • Mycoplasma pneumoniae / classification
  • Mycoplasma pneumoniae / drug effects
  • Mycoplasma pneumoniae / genetics
  • Mycoplasma pneumoniae / isolation & purification*
  • Pneumonia, Mycoplasma / drug therapy*
  • Pneumonia, Mycoplasma / microbiology
  • Salvage Therapy / methods
  • Treatment Failure

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • Ciprofloxacin