Abstract
Two new cassane-type diterpenes, Caesalpinolide F (1) and Caesalpinolide G (2) were isolated from Caesalpinia minax Hance. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested against colon carcinoma (HCT-8) and breast cancer (MCF-7) human cancer cell lines, and showed mild cytotoxicity activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Breast Neoplasms / drug therapy
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Breast Neoplasms / pathology
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Caesalpinia / chemistry*
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Cell Line, Tumor
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Circular Dichroism
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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caesalpinolide F
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caesalpinolide G