A model of hyperhomocysteine-induced endothelial dysfunction in rats

M V Korokin; M V Pokrovskiy; O O Novikov; O S Gudyrev; V V Gureev; T A Denisyuk; L V Korokina; L M Danilenko; V A Ragulina; E A Konovalova; A S Belous

doi:10.1007/s10517-011-1491-9

A model of hyperhomocysteine-induced endothelial dysfunction in rats

Bull Exp Biol Med. 2011 Dec;152(2):213-5. doi: 10.1007/s10517-011-1491-9.

[Article in English, Russian]

Authors

M V Korokin¹, M V Pokrovskiy, O O Novikov, O S Gudyrev, V V Gureev, T A Denisyuk, L V Korokina, L M Danilenko, V A Ragulina, E A Konovalova, A S Belous

Affiliation

¹ Kursk State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Russia. mkorokin@mail.ru

PMID: 22808463
DOI: 10.1007/s10517-011-1491-9

Abstract

Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.

MeSH terms

Animals
Endothelium, Vascular / drug effects
Endothelium, Vascular / pathology*
Hyperhomocysteinemia / complications
Hyperhomocysteinemia / drug therapy
Hyperhomocysteinemia / physiopathology*
Methionine / therapeutic use
Rats
Vascular Diseases / drug therapy
Vascular Diseases / etiology
Vascular Diseases / physiopathology*

Substances

Methionine