Abstract
Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Arginine / chemistry*
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Arginine / metabolism
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Cell Line
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Cell Membrane Permeability
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Cell-Penetrating Peptides / chemistry*
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Cell-Penetrating Peptides / metabolism
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Dogs
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Drug Carriers / chemistry*
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Drug Carriers / metabolism
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Endocytosis
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Escherichia coli
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Fluorescent Dyes
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Luminescent Proteins / chemistry
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Luminescent Proteins / metabolism
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Molecular Imaging
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Molecular Sequence Data
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Recombinant Fusion Proteins / chemistry
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Recombinant Fusion Proteins / metabolism
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Staining and Labeling
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Terbium / chemistry*
Substances
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Cell-Penetrating Peptides
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Drug Carriers
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Fluorescent Dyes
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Luminescent Proteins
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Recombinant Fusion Proteins
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Terbium
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Arginine