The affordance effect has been widely investigated employing various behavioral and brain-imaging techniques. Attempts to interpret the nature of the affordance effect led to two major views. Some researchers compare this kind of compatibility effect to the Simon effect, claiming abstract spatial association between the handle orientation of visually presented stimuli and the nearest response hand. Other authors advocate pure motor activation, during processing of visually presented tools without the involvement of spatial information. However, brain-imaging studies seem to agree that no action can be computed in the absence of spatial information. Taking the latter view into account, a divided visual field experiment was conducted, with the aim of crossing spatial and affordance correspondence effects. Overall, the results supported the view that motor and spatial information go hand in hand. Moreover, the data were in agreement with neuroimaging studies that show tool and affordance processing lateralization in the left hemisphere. The results are discussed in terms of neurophysiological data and brain mechanisms of perception and action.